Utility of alkylaminoquinolinyl methanols as new antimalarial drugs.

Dow, G S; Heady, T N; Bhattacharjee, A K; Caridha, D; Gerena, L; Gettayacamin, M; Lanteri, C A; Obaldia, N; Roncal, N; Shearer, T; Smith, P L; Tungtaeng, A; Wolf, L; Cabezas, M; Yourick, D; Smith, K S

Dow, G S; Heady, T N; Bhattacharjee, A K; Caridha, D; Gerena, L; Gettayacamin, M; Lanteri, C A; Obaldia, N; Roncal, N; Shearer, T; Smith, P L; Tungtaeng, A; Wolf, L; Cabezas, M; Yourick, D; Smith, K S.

Affiliation

Dow GS; Division of Experimental Therapeutics, Walter Reed Army Institute of Research, 503 Robert Grant Ave., Silver Spring, MD 20910, USA. geoffrey.dow@na.amedd.army.mil

Antimicrob Agents Chemother ; 50(12): 4132-43, 2006 Dec.

Article in En | MEDLINE | ID: mdl-16966402

Subject(s)

Antimalarials/pharmacology; Mefloquine/analogs & derivatives; Mefloquine/pharmacology; 3T3 Cells; Animals; Antimalarials/chemical synthesis; Antimalarials/chemistry; Antimalarials/economics; Antimalarials/metabolism; Antimalarials/pharmacokinetics; Antimalarials/toxicity; Aotidae; Computer Simulation; Drug Evaluation, Preclinical; Erythrocytes/parasitology; Female; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Male; Mefloquine/chemical synthesis; Mefloquine/chemistry; Mefloquine/economics; Mefloquine/metabolism; Mefloquine/pharmacokinetics; Mefloquine/toxicity; Mice; Microscopy, Confocal; Molecular Structure; Neurons/drug effects; Neurons/metabolism; Parasitemia/drug therapy; Plasmodium berghei/drug effects; Plasmodium falciparum/drug effects; Plasmodium vivax/drug effects; Solubility; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mefloquine / Antimalarials Type of study: Evaluation_studies Language: En Journal: Antimicrob Agents Chemother Year: 2006 Document type: Article Affiliation country: United States Country of publication: United States

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