Synthesis and biological study of 4-aminopyrimidine-5-carboxaldehyde oximes as antiproliferative VEGFR-2 inhibitors.

Huang, Shenlin; Li, Ronghua; Connolly, Peter J; Xu, Guozhang; Gaul, Michael D; Emanuel, Stuart L; Lamontagne, Kenneth R; Greenberger, Lee M

Huang, Shenlin; Li, Ronghua; Connolly, Peter J; Xu, Guozhang; Gaul, Michael D; Emanuel, Stuart L; Lamontagne, Kenneth R; Greenberger, Lee M.

Affiliation

Huang S; Johnson and Johnson Pharmaceutical Research and Development, L.L.C, 1000 Route 202, Raritan, NJ 08869, USA. shenlinhuang@hotmail.com <shenlinhuang@hotmail.com>

Bioorg Med Chem Lett ; 16(23): 6063-6, 2006 Dec 01.

Article in En | MEDLINE | ID: mdl-16979339

Subject(s)

Oximes/chemistry; Oximes/pharmacology; Protein Kinase Inhibitors/chemical synthesis; Protein Kinase Inhibitors/pharmacology; Pyrimidines/chemical synthesis; Pyrimidines/pharmacology; Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors; Cell Proliferation/drug effects; HeLa Cells; Humans; Molecular Structure; Oximes/chemical synthesis; Protein Kinase Inhibitors/chemistry; Structure-Activity Relationship; Vascular Endothelial Growth Factor Receptor-2/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Oximes / Pyrimidines / Vascular Endothelial Growth Factor Receptor-2 / Protein Kinase Inhibitors Type of study: Prognostic_studies Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2006 Document type: Article Country of publication: United kingdom

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