Universal pathogen-reduced plasma in elective open-heart surgery and liver resection.
Clin Med Res
; 4(3): 209-17, 2006 Sep.
Article
in En
| MEDLINE
| ID: mdl-16988101
ABSTRACT
ABO-incompatible transfusions and transfusion-related lung injury are today the leading transfusion-related causes of death in the developed world. Since anti-A and anti-B antibodies in plasma can give rise to serious, even fatal, transfusion reactions, ABO-identical/compatible plasma is indicated, but presents a logistical challenge and a risk for transfusion of incorrect plasma. In an effort to circumvent these problems, an ABO-independent universally applicable, pathogen-reduced plasma, Uniplas, has been developed and proven safe and efficacious for use in adults through prospective, randomized, controlled open-heart surgery studies and in prospective, parallel group, controlled liver resection studies. The results of these trials are presented and discussed in relation to solvent/detergent (SD) treated plasma, in general. The cost effectiveness of pathogen-reduced plasma is low because of the very low risk for transfusion transmitted viral infections in the developed world (US 2 to 9 million dollars per quality-adjusted life year). However, taking into account the combined safety of Uniplas with regard to transfusion-related lung injury, pathogen reduction and independence of ABO blood groups, the cost per gained life year is reduced to US 40,000 dollars to 100,000 dollars.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plasma
/
Blood Transfusion
Type of study:
Clinical_trials
Aspects:
Patient_preference
Limits:
Humans
Language:
En
Journal:
Clin Med Res
Year:
2006
Document type:
Article
Affiliation country:
Norway