Reactions of sulfenic acid with 2-mercaptoethanol: a mechanism for the inhibition of gastric (H+-K+)-adenosine triphosphate by omeprazole.

Tutunji, Maha F; Qaisi, Ali M; El-Eswed, Bassam I; Tutunji, Lara F

Tutunji, Maha F; Qaisi, Ali M; El-Eswed, Bassam I; Tutunji, Lara F.

Affiliation

Tutunji MF; Department of Chemistry, Faculty of Science, University of Jordan, Amman-Jordan. pru@go.com.jo

J Pharm Sci ; 96(1): 196-208, 2007 Jan.

Article in En | MEDLINE | ID: mdl-16998872

Subject(s)

Enzyme Inhibitors/pharmacology; Mercaptoethanol/chemistry; Omeprazole/pharmacology; Proton Pump Inhibitors; Sulfenic Acids/chemistry; Anti-Ulcer Agents/pharmacology; Buffers; Dimerization; Disulfides/chemistry; Drug Stability; Electrodes; Enzyme Inhibitors/chemistry; Hydrogen-Ion Concentration; Mercury; Models, Chemical; Omeprazole/chemistry; Polarography/instrumentation; Sulfamerazine/chemistry; Sulfhydryl Compounds/chemistry; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Sulfenic Acids / Omeprazole / Enzyme Inhibitors / Proton Pump Inhibitors / Mercaptoethanol Type of study: Prognostic_studies Language: En Journal: J Pharm Sci Year: 2007 Document type: Article Country of publication: United States

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