The effect of CYP2C19 substrate on the metabolism of melatonin in the elderly: A randomized, double-blind, placebo-controlled study.

Huuhka, K; Riutta, A; Haataja, R; Ylitalo, P; Leinonen, E

Huuhka, K; Riutta, A; Haataja, R; Ylitalo, P; Leinonen, E.

Affiliation

Huuhka K; Department of Psychogeriatrics, Tampere University Hospital, Tampere, Finland. kaija.huuhka@pshp.fi

Methods Find Exp Clin Pharmacol ; 28(7): 447-50, 2006 Sep.

Article in En | MEDLINE | ID: mdl-17003850

Subject(s)

Aryl Hydrocarbon Hydroxylases/metabolism; Melatonin/metabolism; Mental Disorders/drug therapy; Mixed Function Oxygenases/metabolism; 2-Pyridinylmethylsulfinylbenzimidazoles/therapeutic use; 2-Pyridinylmethylsulfinylbenzimidazoles/urine; Aged; Aged, 80 and over; Anticonvulsants/metabolism; Anticonvulsants/therapeutic use; Antidepressive Agents, Second-Generation/therapeutic use; Antidepressive Agents, Second-Generation/urine; Citalopram/therapeutic use; Citalopram/urine; Cytochrome P-450 CYP2C19; Double-Blind Method; Drug Therapy, Combination; Enzyme Inhibitors/therapeutic use; Female; Humans; Lansoprazole; Male; Melatonin/analogs & derivatives; Melatonin/therapeutic use; Melatonin/urine; Mental Disorders/metabolism; Omeprazole/therapeutic use; Omeprazole/urine; Selective Serotonin Reuptake Inhibitors/therapeutic use; Selective Serotonin Reuptake Inhibitors/urine; Sleep Wake Disorders/drug therapy; Sleep Wake Disorders/metabolism; Time Factors; Treatment Outcome

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Collection: 01-internacional Database: MEDLINE Main subject: Aryl Hydrocarbon Hydroxylases / Mixed Function Oxygenases / Melatonin / Mental Disorders Type of study: Clinical_trials / Diagnostic_studies Limits: Aged / Aged80 / Female / Humans / Male Language: En Journal: Methods Find Exp Clin Pharmacol Year: 2006 Document type: Article Affiliation country: Finland Country of publication: Spain

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