Synthesis and biological evaluation of a cyclic ether fluorinated noscapine analog.
Bioorg Med Chem
; 14(24): 8352-8, 2006 Dec 15.
Article
in En
| MEDLINE
| ID: mdl-17008104
ABSTRACT
We present here a novel semi-synthetic cyclic ether fluorinated noscapine analog (CEFNA) that shows potent antiproliferative and anticancer activity in both hormone-responsive (MCF-7) and hormone non-responsive (MDA-MB-231) breast cancer cells. Interestingly, it is also effective against MCF-7/Adr, an adriamycin-resistant variant of MCF-7 cells. Immunofluorescence experiments showed numerous micronuclei, indicative of apoptotic cell death triggered by this novel analog. Mechanistically, CEFNA exerts a strong antimitotic effect as revealed by cell-cycle studies that show a dose-dependent increase in G2/M population preceding a rising sub-G1 population, suggesting apoptosis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antitussive Agents
/
Noscapine
Type of study:
Evaluation_studies
Limits:
Humans
Language:
En
Journal:
Bioorg Med Chem
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2006
Document type:
Article
Affiliation country:
United States