Dose-response relationship of DNA and recombinant fowlpox virus prime-boost HIV vaccines: implications for future trials.
Hum Vaccin
; 2(3): 134-6, 2006.
Article
in En
| MEDLINE
| ID: mdl-17012897
ABSTRACT
Estimating effective doses of novel HIV vaccines is challenging. Dose-response analyses of DNA and fowlpox virus HIV vaccines showed that 1 mg of DNA vaccine and 5 x 10(7)pfu of fowlpox virus booster was immunogenic in macaques. However, this dose was poorly immunogenic in humans. When adjusted for body surface area, the human dose studied was equivalent to a poorly immunogenic lower dose in monkeys. These data provide a rationale for guiding dosing in future trials of HIV vaccine technologies.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vaccines, Synthetic
/
AIDS Vaccines
/
Vaccines, DNA
/
Fowlpox virus
Limits:
Animals
/
Humans
Language:
En
Journal:
Hum Vaccin
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2006
Document type:
Article
Affiliation country:
Australia
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA