Tritrichomonas foetus: pathogenesis of acute infection in normal, estradiol-treated, and stressed mice.
Exp Parasitol
; 115(2): 143-59, 2007 Feb.
Article
in En
| MEDLINE
| ID: mdl-17014850
ABSTRACT
Environmental stress and endocrine control can affect pathogenesis of sexually transmitted diseases such as trichomoniasis. Acute Tritrichomonas foetus infection was compared in female BALB/c mice to infections in mice treated with high doses of estradiol or housed in constant bright illumination (stressed). In untreated mice, T. foetus readily colonized the reproductive tract, causing minimal epithelial damage and inflammation. Several fold increases of IFN-gamma, TNF-alpha, MCP-1, and IL-6 cytokines were detected after estradiol-treatment of mice, resulting in greatly enhanced inflammation and tissue damage throughout the reproductive tract. Interestingly, estradiol-treatment of mice resulted in reduced T. foetus colonization compared to untreated mice. Infection in stressed mice resulted in increased tissue damage, inflammation, and inflammatory cytokine expression, although parasite colonization within the reproductive tract was similar to that in untreated mice. These results indicate that either estradiol-treatment or stress result in pathogenesis often observed during severe disease. Alternatively, infection in non-treated mice results in chronic colonization, with little inflammation or pathology.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Protozoan Infections
/
Stress, Physiological
/
Tritrichomonas foetus
/
Estradiol
Type of study:
Etiology_studies
Limits:
Animals
Language:
En
Journal:
Exp Parasitol
Year:
2007
Document type:
Article
Affiliation country:
United States