Cobalt induces hypoxia-inducible factor-1alpha (HIF-1alpha) in HeLa cells by an iron-independent, but ROS-, PI-3K- and MAPK-dependent mechanism.

Triantafyllou, Anastasia; Liakos, Panagiotis; Tsakalof, Andreas; Georgatsou, Elena; Simos, George; Bonanou, Sophia

Triantafyllou, Anastasia; Liakos, Panagiotis; Tsakalof, Andreas; Georgatsou, Elena; Simos, George; Bonanou, Sophia.

Affiliation

Triantafyllou A; Laboratory of Biochemistry, School of Medicine, University of Thessaly, 22 Papakyriazi Street, 41222, Larissa, Greece.

Free Radic Res ; 40(8): 847-56, 2006 Aug.

Article in En | MEDLINE | ID: mdl-17015263

Subject(s)

Cobalt/pharmacology; Hypoxia-Inducible Factor 1, alpha Subunit/biosynthesis; Iron/metabolism; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases/metabolism; Cell Proliferation; Cobalt/metabolism; DNA/metabolism; Deferoxamine/pharmacology; Enzyme Inhibitors/pharmacology; HeLa Cells; Humans; Kinetics; Reactive Oxygen Species; Signal Transduction

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Collection: 01-internacional Database: MEDLINE Main subject: Cobalt / Phosphatidylinositol 3-Kinases / MAP Kinase Signaling System / Hypoxia-Inducible Factor 1, alpha Subunit / Iron Limits: Humans Language: En Journal: Free Radic Res Journal subject: BIOQUIMICA Year: 2006 Document type: Article Affiliation country: Greece Country of publication: United kingdom

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