Expression of calcitonin receptor-like receptor in human vascular tumours.
J Clin Pathol
; 59(10): 1104-7, 2006 Oct.
Article
in En
| MEDLINE
| ID: mdl-17021138
ABSTRACT
BACKGROUND:
Vascular tumours such as Kaposi's sarcoma and capillary haemangioma are characterised by abnormal vascularisation and proliferation of endothelial cells or neoplastic cells. Adrenomedullin, a potent vasodilative peptide, and its receptor, calcitonin receptor-like receptor (CRLR), play an important part in angiogenesis.AIM:
To establish whether this system also plays a part in vascular diseases, showing abnormal proliferation such as vascular tumours.METHODS:
CRLR expression was investigated in several specimens of Kaposi's sarcoma and other vascular tumours, using immunohistochemical analysis with a previously described CRLR-specific polyclonal antibody and reverse transcriptase-polymerase chain reaction.RESULTS:
Intense and specific CRLR-immunoreactive staining of neoplastic cells was observed in all specimens, which was of greater intensity than similar staining of adjacent normal endothelium.CONCLUSIONS:
CRLR is expressed in vascular tumours and, with adrenomedullin, may have a role in neoplastic vascular growth.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, Calcitonin
/
Neoplasms, Vascular Tissue
Limits:
Humans
Language:
En
Journal:
J Clin Pathol
Year:
2006
Document type:
Article
Affiliation country:
Germany
Publication country:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM