Influence of intraarticular corticosteroid administration on serum cytokines in rheumatoid arthritis.
Clin Rheumatol
; 26(5): 845-8, 2007 May.
Article
in En
| MEDLINE
| ID: mdl-17021669
ABSTRACT
Though the efficacy of intraarticular (IA) corticosteroid administration in the therapeutic management of rheumatoid arthritis (RA) has been well documented, its immunomodulatory effects have not been defined. Categorization of these effects is important to develop safe derivative therapeutic strategies with a more targeted mechanism of action as they relate to the pathophysiology of RA. We describe here a broad spectrum immune response to inflammation as evidenced by rapid transient systemic inhibitory effects on key inflammatory regulators induced by the effects of IA administration of triamcinolone acetonide in a case of active RA who failed to respond to methotrexate.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arthritis, Rheumatoid
/
Cytokines
/
Adrenal Cortex Hormones
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
Clin Rheumatol
Year:
2007
Document type:
Article
Affiliation country:
United States