Retrochorionic hematoma in congenital afibrinogenemia: resolution with fibrinogen concentrate infusions.
Am J Hematol
; 82(4): 317-20, 2007 Apr.
Article
in En
| MEDLINE
| ID: mdl-17034026
ABSTRACT
Without treatment, pregnancies in patients with congenital afibrinogenemia terminate in miscarriage at 5-6 weeks of gestation. Animal model studies have suggested that implantation site bleeding contributes to miscarriage in afibrinogenemia; however, retrochorionic hematoma in human congenital afibrinogenemia has not been previously observed. A patient with congenital afibrinogenemia receiving fibrinogen prophylaxis developed a retrochorionic hematoma in the first trimester. With continuous intensified fibrinogen concentrate replacement the hematoma resolved over 6 weeks, and the patient delivered a healthy infant. Median fibrinogen levels in the first trimester were 48 mg/dL and in second and third trimester 44 mg/dL. Median fibrinogen levels under 60 mg/dL may be adequate to maintain pregnancy in patients with congenital afibrinogenemia, although it is possible that higher levels might reduce the risk of hemorrhagic events.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pregnancy Complications, Hematologic
/
Uterine Hemorrhage
/
Blood Coagulation Factors
/
Fibrinogen
/
Afibrinogenemia
/
Hematoma
Type of study:
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Am J Hematol
Year:
2007
Document type:
Article
Affiliation country:
Germany