Recovery of mucosal barrier function in ischemic porcine ileum and colon is stimulated by a novel agonist of the ClC-2 chloride channel, lubiprostone.

Moeser, Adam J; Nighot, Prashant K; Engelke, Kory J; Ueno, Ryuji; Blikslager, Anthony T

Moeser, Adam J; Nighot, Prashant K; Engelke, Kory J; Ueno, Ryuji; Blikslager, Anthony T.

Affiliation

Moeser AJ; Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.

Am J Physiol Gastrointest Liver Physiol ; 292(2): G647-56, 2007 Feb.

Article in En | MEDLINE | ID: mdl-17053162

Subject(s)

Alprostadil/analogs & derivatives; Colon/drug effects; Fatty Acids/pharmacology; Ileum/drug effects; Intestinal Mucosa/drug effects; Alprostadil/pharmacology; Alprostadil/therapeutic use; Animals; Bumetanide/pharmacology; CLC-2 Chloride Channels; Chloride Channel Agonists; Chloride Channels/antagonists & inhibitors; Chlorides/pharmacology; Colon/blood supply; Colon/physiopathology; Cystic Fibrosis Transmembrane Conductance Regulator/antagonists & inhibitors; Dinoprostone/pharmacology; Electric Impedance; Electrophysiology; Fatty Acids/therapeutic use; Female; Ileum/blood supply; Ileum/physiopathology; Indomethacin/pharmacology; Intestinal Mucosa/pathology; Intestinal Mucosa/physiopathology; Ischemia/metabolism; Ischemia/physiopathology; Lubiprostone; Male; Mannitol/metabolism; Membrane Proteins/metabolism; Occludin; Permeability; Recovery of Function/drug effects; Sus scrofa; Urea/analogs & derivatives; Urea/pharmacology; Zinc Compounds/pharmacology

Search on Google

Add to My VHL

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Alprostadil / Colon / Fatty Acids / Ileum / Intestinal Mucosa Language: En Journal: Am J Physiol Gastrointest Liver Physiol Journal subject: FISIOLOGIA / GASTROENTEROLOGIA Year: 2007 Document type: Article Affiliation country: United States Country of publication: United States

Search on Google

Add to My VHL

XML

PubMed Links