Towards the discovery of drug-like RNA ligands?

Foloppe, Nicolas; Matassova, Natalia; Aboul-Ela, Fareed

Foloppe, Nicolas; Matassova, Natalia; Aboul-Ela, Fareed.

Affiliation

Foloppe N; Vernalis (R&D) Ltd., Granta Park, Abington, Cambridge, CB1 6GB, UK.

Drug Discov Today ; 11(21-22): 1019-27, 2006 Nov.

Article in En | MEDLINE | ID: mdl-17055412

Subject(s)

Anti-Bacterial Agents/chemistry; Drug Design; Ligands; Protein Kinase Inhibitors/chemistry; RNA/chemistry; Anti-Bacterial Agents/metabolism; Anti-Bacterial Agents/pharmacology; Binding Sites; Computer-Aided Design; Humans; Models, Molecular; Molecular Structure; Nucleic Acid Conformation; Protein Kinase Inhibitors/metabolism; Protein Kinase Inhibitors/pharmacology; RNA/drug effects; RNA/metabolism; RNA, Bacterial/chemistry; RNA, Ribosomal/chemistry; RNA, Untranslated/chemistry; RNA, Viral/chemistry; Ribosomes/drug effects; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: RNA / Drug Design / Protein Kinase Inhibitors / Ligands / Anti-Bacterial Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: Drug Discov Today Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2006 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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