Late response to radiochemotherapy in pediatric glioblastoma: report on two patients treated according to HIT-GBM protocols.
Pediatr Hematol Oncol
; 23(8): 631-7, 2006 Dec.
Article
in En
| MEDLINE
| ID: mdl-17065139
ABSTRACT
High-grade gliomas in children are rare and the best treatment is undetermined. The German language group study HIT-GBM compares various induction protocols for subsequent patient cohorts. Currently, cisplatinum, etoposide, ifosfamide, and vincristine are given simultaneously with extended-field radiotherapy. Imaging is done 3 weeks after to define treatment response, followed by 6-weekly controls during consolidation with lomustine, vincristine, and prednisone. The authors report on 2 patients with incompletely resected glioblastoma multiforme in which response was lacking 3 weeks after radiochemotherapy but became evident 12 weeks later. This suggests that later time points are required to assess induction protocol response.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Supratentorial Neoplasms
/
Antineoplastic Combined Chemotherapy Protocols
/
Cranial Irradiation
/
Glioblastoma
/
Brain Stem Neoplasms
Type of study:
Clinical_trials
/
Guideline
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Child
/
Humans
/
Male
Language:
En
Journal:
Pediatr Hematol Oncol
Journal subject:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Year:
2006
Document type:
Article
Affiliation country:
Germany