Gymnastatins F-H, cytostatic metabolites from the sponge-derived fungus Gymnascella dankaliensis.
J Nat Prod
; 69(10): 1384-8, 2006 Oct.
Article
in En
| MEDLINE
| ID: mdl-17067147
ABSTRACT
Gymnastatins F -H (2-4) and gymnamide (5) have been isolated from the mycelial MeOH extract of the Halichondria sponge-derived fungus Gymnascella dankaliensis. Their stereostructures have been established on the basis of spectroscopic analyses using 1D and 2D NMR techniques. The stereochemistry of gymnastatin H (4) was determined by its synthesis. Among these compounds, gymnastatins F (2) and G (3) possess a unique bicyclo[3.3.1]nonane ring as natural products, and they were found to exhibit potent growth inhibition against the P388 cancer cell line.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenols
/
Ascomycota
/
Bridged-Ring Compounds
/
Antineoplastic Agents
Limits:
Animals
Country/Region as subject:
Asia
Language:
En
Journal:
J Nat Prod
Year:
2006
Document type:
Article