3,4-methylenedioxymethamphetamine (MDMA): an important cause of acute hepatitis.
Med Sci Monit
; 12(11): CS107-9, 2006 Nov.
Article
in En
| MEDLINE
| ID: mdl-17072276
ABSTRACT
BACKGROUND:
MDMA, i.e. 3,4-methylenedioxymethamphetamine ("Ecstasy"), occasionally produces significant hepatotoxicity in humans. It is characterized by a wide range of variability in clinical expression, ranging from asymptomatic liver injury, as observed by altered liver function tests, to acute hepatic failure. Prognostic factors that may predict the outcome of this condition remain unknown. CASE REPORT We report a case of a 19-year-old male who presented deeplyjaundiced two weeks after ingestion of two tablets of Ecstasy. The clinical picture, laboratory data, and morphological studies were consistent with acute hepatitis. There was no evidence for a viral, alcoholic, metabolic, or autoimmune etiology of the disease. A mild clinical course with complete recovery after two months was observed. The presence of All molecule was confirmed in the patient.CONCLUSIONS:
The possible association of specific human leukocyte antigen (HLA) phenotypes and MDMA-induced hepatotoxicity needs future evaluation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
N-Methyl-3,4-methylenedioxyamphetamine
/
Chemical and Drug Induced Liver Injury
/
Hallucinogens
/
Liver
Type of study:
Prognostic_studies
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
Med Sci Monit
Journal subject:
MEDICINA
Year:
2006
Document type:
Article
Affiliation country:
Croatia