Anticancer drug discovery and pharmaceutical chemistry: a history.
Clin Transl Oncol
; 8(10): 717-28, 2006 Oct.
Article
in En
| MEDLINE
| ID: mdl-17074670
ABSTRACT
There are several procedures for the chemical discovery and design of new drugs from the point of view of the pharmaceutical or medicinal chemistry. They range from classical methods to the very new ones, such as molecular modeling or high throughput screening. In this review, we will consider some historical approaches based on the screening of natural products, the chances for luck, the systematic screening of new chemical entities and serendipity. Another group comprises rational design, as in the case of metabolic pathways, conformation versus configuration and, finally, a brief description on available new targets to be carried out. In each approach, the structure of some examples of clinical interest will be shown.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Biological Products
/
Pharmaceutical Preparations
/
Drug Design
/
Chemistry, Organic
/
Chemistry, Pharmaceutical
/
Drug Evaluation, Preclinical
/
Antineoplastic Agents
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Clin Transl Oncol
Year:
2006
Document type:
Article
Affiliation country:
Spain