FK-506 and cyclosporin A inhibit highly similar signal transduction pathways in human T lymphocytes.

Lin, C S; Boltz, R C; Siekierka, J J; Sigal, N H

Lin, C S; Boltz, R C; Siekierka, J J; Sigal, N H.

Affiliation

Lin CS; Department of Immunology Research, Merck, Sharp and Dohme Research Laboratories, Rahway, New Jersey 07065.

Cell Immunol ; 133(2): 269-84, 1991 Apr 01.

Article in En | MEDLINE | ID: mdl-1707760

Subject(s)

Anti-Bacterial Agents/pharmacology; Cyclosporins/pharmacology; Immunosuppressive Agents/pharmacology; Signal Transduction/drug effects; T-Lymphocytes/drug effects; Antigens, Differentiation, T-Lymphocyte/physiology; CD2 Antigens; CD28 Antigens; CD3 Complex; Calcium/metabolism; Cells, Cultured; Humans; Interleukin-2/biosynthesis; Lymphocyte Activation/drug effects; Receptors, Antigen, T-Cell/physiology; Receptors, Immunologic/physiology; T-Lymphocytes/immunology; Tacrolimus; Tetradecanoylphorbol Acetate/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / Signal Transduction / Cyclosporins / Immunosuppressive Agents / Anti-Bacterial Agents Limits: Humans Language: En Journal: Cell Immunol Year: 1991 Document type: Article Country of publication: Netherlands

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