Highly constrained bicyclic VLA-4 antagonists.

Chang, Linda L; Truong, Quang; Doss, George A; MacCoss, Malcolm; Lyons, Kathryn; McCauley, Ermengilda; Mumford, Richard; Forrest, Gail; Vincent, Stella; Schmidt, John A; Hagmann, William K

Chang, Linda L; Truong, Quang; Doss, George A; MacCoss, Malcolm; Lyons, Kathryn; McCauley, Ermengilda; Mumford, Richard; Forrest, Gail; Vincent, Stella; Schmidt, John A; Hagmann, William K.

Affiliation

Chang LL; Department of Medicinal Chemical Research, Merck Research Laboratories, Rahway, NJ 07065, USA.

Bioorg Med Chem Lett ; 17(3): 597-601, 2007 Feb 01.

Article in En | MEDLINE | ID: mdl-17118652

Subject(s)

Bridged Bicyclo Compounds/chemical synthesis; Bridged Bicyclo Compounds/pharmacology; Integrin alpha4beta1/antagonists & inhibitors; Biological Availability; Bridged Bicyclo Compounds/pharmacokinetics; Half-Life; Humans; Indicators and Reagents; Integrins/metabolism; Jurkat Cells; Magnetic Resonance Spectroscopy; Molecular Conformation; Stereoisomerism; Structure-Activity Relationship; Vascular Cell Adhesion Molecule-1/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Bridged Bicyclo Compounds / Integrin alpha4beta1 Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2007 Document type: Article Affiliation country: United States Country of publication: United kingdom

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