Vitamin C prevents zidovudine-induced NAD(P)H oxidase activation and hypertension in the rat.

Papparella, Italia; Ceolotto, Giulio; Berto, Laura; Cavalli, Maurizio; Bova, Sergio; Cargnelli, Gabriella; Ruga, Ezia; Milanesi, Ornella; Franco, Lorenzo; Mazzoni, Martina; Petrelli, Lucia; Nussdorfer, Gastone G; Semplicini, Andrea

Papparella, Italia; Ceolotto, Giulio; Berto, Laura; Cavalli, Maurizio; Bova, Sergio; Cargnelli, Gabriella; Ruga, Ezia; Milanesi, Ornella; Franco, Lorenzo; Mazzoni, Martina; Petrelli, Lucia; Nussdorfer, Gastone G; Semplicini, Andrea.

Affiliation

Papparella I; Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, I-35128 Padua, Italy.

Cardiovasc Res ; 73(2): 432-8, 2007 Jan 15.

Article in En | MEDLINE | ID: mdl-17123493

Subject(s)

Antimetabolites/pharmacology; Ascorbic Acid/pharmacology; Hypertension/prevention & control; NADPH Oxidases/metabolism; Vitamins/pharmacology; Zidovudine/pharmacology; Animals; Antioxidants/metabolism; Blotting, Western/methods; Enzyme Activation/drug effects; Hypertension/metabolism; Hypertension/pathology; Male; Membrane Glycoproteins/analysis; Membrane Glycoproteins/metabolism; Microscopy, Electron; Myocytes, Cardiac/drug effects; Myocytes, Cardiac/metabolism; Myocytes, Cardiac/ultrastructure; NADPH Oxidase 2; NADPH Oxidases/analysis; Nuclear Proteins/analysis; Nuclear Proteins/metabolism; Protein Kinase C/metabolism; Rats; Rats, Inbred WKY; Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins

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Collection: 01-internacional Database: MEDLINE Main subject: Ascorbic Acid / Vitamins / Zidovudine / NADPH Oxidases / Hypertension / Antimetabolites Limits: Animals Language: En Journal: Cardiovasc Res Year: 2007 Document type: Article Affiliation country: Italy Country of publication: United kingdom

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