Aplastic crisis as a complication of congenital dyserythropoietic anemia type II.
Acta Haematol
; 117(2): 115-8, 2007.
Article
in En
| MEDLINE
| ID: mdl-17127819
ABSTRACT
A transient aplastic crisis (TAC) is a well-known complication in all types of chronic hemolytic anemia but only 2 cases of such an event were described in congenital dyserythropoietic anemias (CDAs). Here, we report a third case, and by retrospective chart review of 78 cases we found evidence of TAC in 8 further patients with CDA II, with serological evidence of previous human parvovirus B19 (B19V) infection in all but one. Although B19V infection results in TAC in only a minority of patients with CDA, physicians responsible for these patients should be aware of such a potentially life-threatening complication. Testing for B19V-specific IgG is recommended in patients with CDA to estimate the risk of a possible future aplastic crisis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Red-Cell Aplasia, Pure
/
Anemia, Dyserythropoietic, Congenital
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Child, preschool
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Acta Haematol
Year:
2007
Document type:
Article