Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cells.

Cang, Yong; Zhang, Jianxuan; Nicholas, Sally A; Bastien, Jayson; Li, Baojie; Zhou, Pengbo; Goff, Stephen P

Cang, Yong; Zhang, Jianxuan; Nicholas, Sally A; Bastien, Jayson; Li, Baojie; Zhou, Pengbo; Goff, Stephen P.

Affiliation

Cang Y; Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

Cell ; 127(5): 929-40, 2006 Dec 01.

Article in En | MEDLINE | ID: mdl-17129780

Subject(s)

Brain/cytology; DNA-Binding Proteins/deficiency; Gene Deletion; Lens, Crystalline/cytology; Tumor Suppressor Protein p53/metabolism; Alleles; Animals; Animals, Newborn; Apoptosis; Brain/abnormalities; Brain/embryology; Brain/pathology; Cell Cycle Proteins/metabolism; Cell Proliferation; Cell Survival; DNA Damage; DNA-Binding Proteins/metabolism; Embryo, Mammalian/cytology; Embryonic Development; Fibroblasts/cytology; Gene Targeting; Hemorrhage/pathology; Lens, Crystalline/abnormalities; Lens, Crystalline/pathology; Mice; Mitosis; Neurons/cytology; Stem Cells/cytology; Tumor Suppressor Protein p53/deficiency

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Collection: 01-internacional Database: MEDLINE Main subject: Brain / Tumor Suppressor Protein p53 / Gene Deletion / DNA-Binding Proteins / Lens, Crystalline Limits: Animals Language: En Journal: Cell Year: 2006 Document type: Article Affiliation country: United States Country of publication: United States

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