Correction of head movement on PET studies: comparison of methods.
J Nucl Med
; 47(12): 1936-44, 2006 Dec.
Article
in En
| MEDLINE
| ID: mdl-17138736
ABSTRACT
UNLABELLED Head movement presents a continuing problem in PET studies. Head restraint minimizes movement but is unreliable, resulting in the need to develop alternative strategies. These include frame-by-frame (FBF) realignment or use of motion tracking (MT) during the scan to realign PET acquisition data. Here we present a comparative analysis of these 2 methods of motion correction. METHODS:
Eight volunteers were examined at rest using (11)C-raclopride PET with the radioligand administered as a bolus followed by constant infusion to achieve steady state. Binding potential (BP) was estimated using the ratio method during 2 periods of the scan at steady state. Head movement was compensated by using coregistration between frames (FBF) and 3 methods using MT measurements of head position acquired with a commercially available optical tracking system.RESULTS:
All methods of realignment improved test-retest reliability and noise characteristics of the raw data, with important consequences for the power to detect small changes in radiotracer binding, and the potential to reduce false-positive and false-negative results. MT methods were superior to FBF realignment using coregistration on some indices.CONCLUSION:
Such methods have considerable potential to improve the reliability of PET data with important implications for the numbers of volunteers required to test hypotheses.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Algorithms
/
Brain
/
Image Interpretation, Computer-Assisted
/
Image Enhancement
/
Artifacts
/
Head Movements
/
Positron-Emission Tomography
Type of study:
Diagnostic_studies
/
Evaluation_studies
Limits:
Humans
Language:
En
Journal:
J Nucl Med
Year:
2006
Document type:
Article
Affiliation country:
United kingdom