Strategy for genotoxicity testing--metabolic considerations.

Ku, Warren W; Bigger, Anita; Brambilla, Giovanni; Glatt, Hansruedi; Gocke, Elmar; Guzzie, Peggy J; Hakura, Atsushi; Honma, Masamitsu; Martus, Hans-Joerg; Obach, R Scott; Roberts, Stanley

Ku, Warren W; Bigger, Anita; Brambilla, Giovanni; Glatt, Hansruedi; Gocke, Elmar; Guzzie, Peggy J; Hakura, Atsushi; Honma, Masamitsu; Martus, Hans-Joerg; Obach, R Scott; Roberts, Stanley.

Affiliation

Ku WW; Pfizer Global Research and Development, Drug Safety Research and Development, Groton, CT 06340, USA. warren.w.ku@pfizer.com

Mutat Res ; 627(1): 59-77, 2007 Feb 03.

Article in En | MEDLINE | ID: mdl-17141553

Subject(s)

Metabolic Networks and Pathways; Mutagenicity Tests/methods; 2-Acetylaminofluorene/metabolism; 2-Acetylaminofluorene/toxicity; Animals; Carcinogens/toxicity; Cytochrome P-450 Enzyme System/genetics; Cytochrome P-450 Enzyme System/metabolism; Drug Industry; Enzymes/chemistry; Guidelines as Topic; Humans; Liver/metabolism; Mutagenicity Tests/standards; Mutagenicity Tests/trends; Plant Extracts/metabolism; Recombinant Proteins/drug effects; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Solvents/chemistry; United States; United States Food and Drug Administration

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Collection: 01-internacional Database: MEDLINE Main subject: Metabolic Networks and Pathways / Mutagenicity Tests Type of study: Guideline / Prognostic_studies Limits: Animals / Humans Country/Region as subject: America do norte Language: En Journal: Mutat Res Year: 2007 Document type: Article Affiliation country: United States Country of publication: Netherlands

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