The role of NAD(P)H: quinone reductase (EC 1.6.99.2, DT-diaphorase) in the reductive bioactivation of the novel indoloquinone antitumor agent EO9.

Walton, M I; Smith, P J; Workman, P

Walton, M I; Smith, P J; Workman, P.

Affiliation

Walton MI; MRC Clinical Oncology and Radiotherapeutics Unit, Cambridge, UK.

Cancer Commun ; 3(7): 199-206, 1991 Jul.

Article in En | MEDLINE | ID: mdl-1714284

Subject(s)

Antineoplastic Agents/metabolism; Aziridines/metabolism; Indolequinones; Indoles/metabolism; Quinone Reductases/metabolism; Animals; Biotransformation; Carcinoma 256, Walker/enzymology; Colonic Neoplasms/enzymology; DNA Damage; DNA, Bacterial/drug effects; Dicumarol/pharmacology; Humans; Kinetics; Mitomycin; Mitomycins/metabolism; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Quinones/metabolism; Rats; Superoxide Dismutase/pharmacology; Tumor Cells, Cultured; Vitamin K/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Quinone Reductases / Aziridines / Indolequinones / Indoles / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Cancer Commun Journal subject: NEOPLASIAS Year: 1991 Document type: Article Affiliation country: United kingdom

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