Quercetin mediates preferential degradation of oncogenic Ras and causes autophagy in Ha-RAS-transformed human colon cells.

Psahoulia, Faiy H; Moumtzi, Sophy; Roberts, Michael L; Sasazuki, Takehiko; Shirasawa, Senji; Pintzas, Alexander

Psahoulia, Faiy H; Moumtzi, Sophy; Roberts, Michael L; Sasazuki, Takehiko; Shirasawa, Senji; Pintzas, Alexander.

Affiliation

Psahoulia FH; Laboratory of Signal Mediated Gene Expression, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, 48 Vas. Konstantinou Avenue, Athens 11635, Greece.

Carcinogenesis ; 28(5): 1021-31, 2007 May.

Article in En | MEDLINE | ID: mdl-17148506

Subject(s)

Autophagy/drug effects; Colonic Neoplasms/genetics; Genes, ras/drug effects; Quercetin/pharmacology; Cell Proliferation/drug effects; Cell Transformation, Neoplastic; Colon; Humans; Leupeptins/antagonists & inhibitors; Oncogene Protein p21(ras); Tumor Cells, Cultured; ras Proteins/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Quercetin / Autophagy / Genes, ras / Colonic Neoplasms Type of study: Etiology_studies Limits: Humans Language: En Journal: Carcinogenesis Year: 2007 Document type: Article Affiliation country: Greece

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