In the absence of IGF-1 signaling, IFN-gamma suppresses human malignant T-cell growth.

Conti, Laura; Regis, Gabriella; Longo, Angela; Bernabei, Paola; Chiarle, Roberto; Giovarelli, Mirella; Novelli, Francesco

Conti, Laura; Regis, Gabriella; Longo, Angela; Bernabei, Paola; Chiarle, Roberto; Giovarelli, Mirella; Novelli, Francesco.

Affiliation

Conti L; Center for Experimental Research and Medical Studies (CERMS), San Giovanni Battista Hospital, Turin, Italy.

Blood ; 109(6): 2496-504, 2007 Mar 15.

Article in En | MEDLINE | ID: mdl-17148586

Subject(s)

Down-Regulation; Insulin-Like Growth Factor I/pharmacology; Interferon-gamma/metabolism; Leukemia, T-Cell/metabolism; Leukemia, T-Cell/pathology; Signal Transduction/drug effects; Animals; Apoptosis; Cell Line, Tumor; Female; Humans; Insulin-Like Growth Factor I/metabolism; Mice; Podophyllotoxin/analogs & derivatives; Podophyllotoxin/pharmacology; Receptor, IGF Type 1/genetics; Receptor, IGF Type 1/metabolism; Receptors, Interferon/metabolism; STAT1 Transcription Factor/metabolism; Sensitivity and Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Insulin-Like Growth Factor I / Leukemia, T-Cell / Signal Transduction / Down-Regulation / Interferon-gamma Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Blood Year: 2007 Document type: Article Affiliation country: Italy Country of publication: United States

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