Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor.

Koehler, Konrad; Gordon, Sandra; Brandt, Peter; Carlsson, Bo; Bäcksbro-Saeidi, Anna; Apelqvist, Theresa; Agback, Peter; Grover, Gary J; Nelson, William; Grynfarb, Marlena; Färnegårdh, Mathias; Rehnmark, Stefan; Malm, Johan

Koehler, Konrad; Gordon, Sandra; Brandt, Peter; Carlsson, Bo; Bäcksbro-Saeidi, Anna; Apelqvist, Theresa; Agback, Peter; Grover, Gary J; Nelson, William; Grynfarb, Marlena; Färnegårdh, Mathias; Rehnmark, Stefan; Malm, Johan.

Affiliation

Koehler K; Karo Bio AB, Novum, Huddinge SE-141 57, Sweden.

J Med Chem ; 49(23): 6635-7, 2006 Nov 16.

Article in En | MEDLINE | ID: mdl-17154490

Subject(s)

Phenylpropionates/chemical synthesis; Pyridines/chemical synthesis; Receptors, Thyroid Hormone/antagonists & inhibitors; Animals; CHO Cells; Cricetinae; Cricetulus; Humans; Ligands; Models, Molecular; Phenylpropionates/chemistry; Phenylpropionates/pharmacology; Pyridines/chemistry; Pyridines/pharmacology; Rats; Thyroid Hormone Receptors alpha/antagonists & inhibitors; Thyroid Hormone Receptors beta/antagonists & inhibitors; Thyroid Hormone Receptors beta/chemistry; Transcriptional Activation/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Phenylpropionates / Pyridines / Receptors, Thyroid Hormone Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2006 Document type: Article Affiliation country: Sweden Country of publication: United States

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