Human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis: viral load and muscle tone are correlated.
J Neurovirol
; 12(6): 466-71, 2006 Dec.
Article
in En
| MEDLINE
| ID: mdl-17162662
ABSTRACT
Human T-lymphotropic virus type 1 (HTLV-1) infections are associated with varying degrees of HTLV-1 viral load and spasticity. Increased viral load is associated with higher risk of developing HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The authors performed a cross-sectional study of 24 people with HAM/TSP in Lima, Perú, to determine if higher HTLV-1 viral load was correlated with increased muscle tone, measured with a device providing quantitative spasticity assessment (QSA). Median HTLV-1 viral load was 17.0 copies/100 peripheral blood mononuclear cells and QSA value was 39.9 Newton-meters/radian. HTLV-1 viral load was significantly correlated with QSA value (Spearman rho = .48, P = .02), suggesting viral load may play a role in expression of symptomatic neurologic disease. Longitudinal studies are needed to determine if treatments that reduce viral load will reduce muscle tone.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Human T-lymphotropic virus 1
/
Paraparesis, Tropical Spastic
/
Viral Load
/
Muscle Tonus
Type of study:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
America do sul
/
Peru
Language:
En
Journal:
J Neurovirol
Journal subject:
NEUROLOGIA
/
VIROLOGIA
Year:
2006
Document type:
Article
Affiliation country:
United States