Toxicological study of the hepatotherapeutic herbal formula, chunggan extract, in beagle dogs.
World J Gastroenterol
; 12(46): 7497-502, 2006 Dec 14.
Article
in En
| MEDLINE
| ID: mdl-17167840
ABSTRACT
AIM:
To evaluate the pharmaceutical safety of a Chinese herbal formula, chunggan extract (CGX), traditionally prescribed as a hepatotherapeutic drug via systemic acute and subacute toxicological study.METHODS:
Twenty male dogs and 20 female dogs were fed doses 50 times and 4 times greater than the clinically-recommended drug dosages in an acute and a subacute toxicological study, respectively. Adverse effects were examined by comparing the differences between normal and drug-administered groups using clinical signs, necropsies, histopathologic findings, haematology, urinalysis, and biochemical analysis.RESULTS:
In the acute study no change in the body weight, diarrhoea, apetite, mortality rate and histopathology of major organs was observed in male or female dogs with a single administration of CGX at 5 g/kg. No drug-induced abnormalities at analysis of histopathology, haematology, urinalysis, and biochemistry were found with any dose of this drug.CONCLUSION:
CGX is supposed to be very safe when used in a clinical application with a wide therapeutic index.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drugs, Chinese Herbal
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
En
Journal:
World J Gastroenterol
Journal subject:
GASTROENTEROLOGIA
Year:
2006
Document type:
Article
Affiliation country:
South Korea