Identification of Leu276 of the S1P1 receptor and Phe263 of the S1P3 receptor in interaction with receptor specific agonists by molecular modeling, site-directed mutagenesis, and affinity studies.

Deng, Qiaolin; Clemas, Joseph A; Chrebet, Gary; Fischer, Paul; Hale, Jeffrey J; Li, Zhen; Mills, Sander G; Bergstrom, James; Mandala, Suzanne; Mosley, Ralph; Parent, Stephen A

Deng, Qiaolin; Clemas, Joseph A; Chrebet, Gary; Fischer, Paul; Hale, Jeffrey J; Li, Zhen; Mills, Sander G; Bergstrom, James; Mandala, Suzanne; Mosley, Ralph; Parent, Stephen A.

Affiliation

Deng Q; Department of Molecular Systems, Merck Research Laboratories, PO Box 2000, RY80Y-225, Rahway, NJ 07065, USA.

Mol Pharmacol ; 71(3): 724-35, 2007 Mar.

Article in En | MEDLINE | ID: mdl-17170199

Subject(s)

Immunosuppressive Agents/pharmacology; Receptors, Lysosphingolipid/agonists; Receptors, Lysosphingolipid/chemistry; Amino Acid Sequence; Animals; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Lysosphingolipid / Immunosuppressive Agents Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Mol Pharmacol Year: 2007 Document type: Article Affiliation country: United States Country of publication: United States

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