Design, synthesis, and biological evaluation of phenylamino-substituted 6,11-dihydro-dibenzo[b,e]oxepin-11-ones and dibenzo[a,d]cycloheptan-5-ones: novel p38 MAP kinase inhibitors.

Laufer, Stefan A; Ahrens, Gabriele M; Karcher, Solveigh C; Hering, Jörg S; Niess, Raimund

Laufer, Stefan A; Ahrens, Gabriele M; Karcher, Solveigh C; Hering, Jörg S; Niess, Raimund.

Affiliation

Laufer SA; Institute of Pharmacy, Department of Pharmaceutical and Medicinal Chemistry, Eberhard-Karls-Universität, Auf der Morgenstelle 8, 72076 Tübingen, Germany. stefan.laufer@uni-tuebingen.de

J Med Chem ; 49(26): 7912-5, 2006 Dec 28.

Article in En | MEDLINE | ID: mdl-17181176

Subject(s)

Drug Design; Oxepins/chemical synthesis; Oxepins/pharmacology; Protein Kinase Inhibitors/chemical synthesis; Protein Kinase Inhibitors/pharmacology; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System/metabolism; Humans; Molecular Structure; Oxepins/chemistry; Protein Kinase Inhibitors/chemistry; Structure-Activity Relationship; p38 Mitogen-Activated Protein Kinases/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Oxepins / Drug Design / P38 Mitogen-Activated Protein Kinases / Protein Kinase Inhibitors Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2006 Document type: Article Affiliation country: Germany Country of publication: United States

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