Novel DNA lesions generated by the interaction between therapeutic thiopurines and UVA light.

Zhang, Xiaohong; Jeffs, Graham; Ren, Xiaolin; O'Donovan, Peter; Montaner, Beatriz; Perrett, Conal M; Karran, Peter; Xu, Yao-Zhong

Zhang, Xiaohong; Jeffs, Graham; Ren, Xiaolin; O'Donovan, Peter; Montaner, Beatriz; Perrett, Conal M; Karran, Peter; Xu, Yao-Zhong.

Affiliation

Zhang X; Department of Chemistry, The Open University, Walton Hall, Milton Keynes MK7 6AA, UK.

DNA Repair (Amst) ; 6(3): 344-54, 2007 Mar 01.

Article in En | MEDLINE | ID: mdl-17188583

Subject(s)

Antimetabolites, Antineoplastic/radiation effects; Antimetabolites, Antineoplastic/toxicity; DNA Damage; Thioguanine/radiation effects; Thioguanine/toxicity; Ultraviolet Rays; Antimetabolites, Antineoplastic/chemistry; Arylsulfonates/chemistry; Arylsulfonates/metabolism; Cell Line, Tumor; DNA/chemistry; DNA/metabolism; DNA/radiation effects; DNA Replication; Dose-Response Relationship, Radiation; Female; Guanine/analogs & derivatives; Guanine/chemistry; Guanine/metabolism; Humans; Oxidants, Photochemical/metabolism; Oxidation-Reduction/radiation effects; Thioguanine/analogs & derivatives; Thioguanine/chemistry; Thioguanine/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Thioguanine / Ultraviolet Rays / DNA Damage / Antimetabolites, Antineoplastic Limits: Female / Humans Language: En Journal: DNA Repair (Amst) Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA Year: 2007 Document type: Article Affiliation country: United kingdom Country of publication: Netherlands

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