Immunologic and clinical effects of injecting mature peptide-loaded dendritic cells by intralymphatic and intranodal routes in metastatic melanoma patients.

Lesimple, Thierry; Neidhard, Eve-Marie; Vignard, Virginie; Lefeuvre, Claudia; Adamski, Henri; Labarrière, Nathalie; Carsin, André; Monnier, Delphine; Collet, Brigitte; Clapisson, Gilles; Birebent, Brigitte; Philip, Irène; Toujas, Louis; Chokri, Mohamed; Quillien, Véronique

Lesimple, Thierry; Neidhard, Eve-Marie; Vignard, Virginie; Lefeuvre, Claudia; Adamski, Henri; Labarrière, Nathalie; Carsin, André; Monnier, Delphine; Collet, Brigitte; Clapisson, Gilles; Birebent, Brigitte; Philip, Irène; Toujas, Louis; Chokri, Mohamed; Quillien, Véronique.

Affiliation

Lesimple T; Centre Eugène Marquis, Rennes, France.

Clin Cancer Res ; 12(24): 7380-8, 2006 Dec 15.

Article in En | MEDLINE | ID: mdl-17189411

Subject(s)

Dendritic Cells/transplantation; Immunotherapy, Adoptive/methods; Melanoma/therapy; Skin Neoplasms/therapy; Adult; Aged; Aged, 80 and over; Antibody Formation; Antigens, Neoplasm/chemistry; Antigens, Neoplasm/immunology; Cancer Vaccines/adverse effects; Cancer Vaccines/analysis; Cancer Vaccines/therapeutic use; Dendritic Cells/chemistry; Disease-Free Survival; Female; Humans; Immunity, Cellular; Immunotherapy, Adoptive/adverse effects; Injections, Intralymphatic/methods; Lymphatic Metastasis/immunology; Lymphatic Metastasis/pathology; MART-1 Antigen; Male; Melanoma/immunology; Melanoma/mortality; Middle Aged; Neoplasm Proteins/chemistry; Neoplasm Proteins/immunology; Peptides/chemistry; Peptides/immunology; Skin Neoplasms/immunology; Skin Neoplasms/mortality; Survival Analysis; Treatment Outcome

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Collection: 01-internacional Database: MEDLINE Main subject: Skin Neoplasms / Dendritic Cells / Immunotherapy, Adoptive / Melanoma Type of study: Clinical_trials Limits: Aged80 Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2006 Document type: Article Affiliation country: France Country of publication: United States

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