Preclinical evaluation of antiangiogenic thrombospondin-1 peptide mimetics, ABT-526 and ABT-510, in companion dogs with naturally occurring cancers.

Rusk, Anthony; McKeegan, Evelyn; Haviv, Fortuna; Majest, Sandra; Henkin, Jack; Khanna, Chand

Rusk, Anthony; McKeegan, Evelyn; Haviv, Fortuna; Majest, Sandra; Henkin, Jack; Khanna, Chand.

Affiliation

Rusk A; Animal Clinical Investigation, LLC, Columbia, Maryland, USA. trusk@animalci.com

Clin Cancer Res ; 12(24): 7444-55, 2006 Dec 15.

Article in En | MEDLINE | ID: mdl-17189418

Subject(s)

Angiogenesis Inhibitors/therapeutic use; Neoplasms/drug therapy; Oligopeptides/therapeutic use; Peptide Fragments/therapeutic use; Thrombospondin 1/therapeutic use; Angiogenesis Inhibitors/adverse effects; Angiogenesis Inhibitors/blood; Angiogenesis Inhibitors/pharmacology; Animals; Cell Movement/drug effects; Dogs; Drug Screening Assays, Antitumor; Endothelial Cells/drug effects; Female; Humans; Male; Oligopeptides/adverse effects; Oligopeptides/blood; Oligopeptides/pharmacology; Peptide Fragments/adverse effects; Peptide Fragments/blood; Peptide Fragments/pharmacology; Thrombospondin 1/adverse effects; Thrombospondin 1/agonists; Thrombospondin 1/blood; Thrombospondin 1/pharmacology; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Peptide Fragments / Thrombospondin 1 / Angiogenesis Inhibitors / Neoplasms Type of study: Clinical_trials Limits: Animals / Female / Humans / Male Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2006 Document type: Article Affiliation country: United States Country of publication: United States

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