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ACE I/D polymorphism study in a Cuban hypertensive population.
Companioni Nápoles, Osmel; Sautié Castellanos, Miguel; Leal, Lester; Casalvilla, Racmar; Camacho, Hamlet; Ferrer, Annia; Cintado, Alberto; Villareal, Adelaida; Benítez, Jesús V; Nazabal, Marcelo; Velasco, Javier García Pérez; Cabalé, Beatriz; Novoa, Lidia I; Dueñas, Marta.
Affiliation
  • Companioni Nápoles O; Genomics Department, Center for Genetic Engineering and Biotechnology, Havana City, Cuba. osmel@cigb.edu.cu
Clin Chim Acta ; 378(1-2): 112-6, 2007 Mar.
Article in En | MEDLINE | ID: mdl-17196575
BACKGROUND: The angiotensin converting enzyme (ACE) is a key protein of the renin angiotensin system, whose main function is the conversion of angiotensin I to II. ACE is involved in the physiological control of blood pressure and it is a candidate gene for essential hypertension in humans. We tested the relevance of the ACE insertion/deletion (I/D) polymorphism in our population. METHODS: We recruited 243 hypertensive and 407 normotensive subjects in the city of Havana, matched according to age, sex and ethnic group. The ACE (I/D) polymorphism was determined by the polymerase chain reaction (PCR) technique. The fit of genotype frequencies to Hardy-Weinberg proportions was evaluated in all groups analyzed. The possible association between the ACE I/D polymorphism and hypertension status was tested by chi2 and odds ratio tests. RESULTS: All groups but black female cases were in Hardy-Weinberg equilibrium. The frequencies of the D allele in hypertensive/normotensive subjects were 0.61/0.59 in white males, 0.58/0.58 in white females, 0.47/0.59 in black males and 0.58/0.54 in black females. The distribution of ACE genotypes differed significantly between cases and controls only in black women according to the additive model (chi2p=0.04) but the adjusted OR did not show significant association (OR 1.14 95% CI 0.62 to 2.10). CONCLUSION: The ACE I/D polymorphism was not associated with hypertension in our multiethnic sample. While the chi2 test for additive model in black women suggested a marginal significance, the adjusted OR did not show any significant association.
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Collection: 01-internacional Database: MEDLINE Main subject: Polymorphism, Genetic / Peptidyl-Dipeptidase A / Hypertension Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Caribe / Cuba Language: En Journal: Clin Chim Acta Year: 2007 Document type: Article Affiliation country: Cuba Country of publication: Netherlands
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Collection: 01-internacional Database: MEDLINE Main subject: Polymorphism, Genetic / Peptidyl-Dipeptidase A / Hypertension Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Caribe / Cuba Language: En Journal: Clin Chim Acta Year: 2007 Document type: Article Affiliation country: Cuba Country of publication: Netherlands