VLA-4 blockade suppresses endotoxin-induced uveitis: in vivo evidence for functional integrin up-regulation.

Hafezi-Moghadam, A; Noda, K; Almulki, L; Iliaki, E F; Poulaki, V; Thomas, K L; Nakazawa, T; Hisatomi, T; Miller, J W; Gragoudas, E S

Hafezi-Moghadam, A; Noda, K; Almulki, L; Iliaki, E F; Poulaki, V; Thomas, K L; Nakazawa, T; Hisatomi, T; Miller, J W; Gragoudas, E S.

Affiliation

Hafezi-Moghadam A; Department of Ophthalmology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, Massachusetts, USA. ahm@meei.harvard.edu

FASEB J ; 21(2): 464-74, 2007 Feb.

Article in En | MEDLINE | ID: mdl-17202250

Subject(s)

Endotoxins/toxicity; Integrin alpha4beta1/metabolism; Integrins/metabolism; Uveitis/metabolism; Animals; Antibodies, Monoclonal/pharmacology; Blotting, Western; Cell Adhesion/drug effects; Endothelium, Vascular/metabolism; Eye Proteins/metabolism; Integrin alpha4beta1/immunology; Integrin alpha4beta1/physiology; Integrins/physiology; Leukocytes/cytology; Leukocytes/drug effects; Leukocytes/metabolism; Rats; Time Factors; Up-Regulation/drug effects; Uveitis/chemically induced; Uveitis/physiopathology; Vascular Cell Adhesion Molecule-1/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Uveitis / Integrins / Integrin alpha4beta1 / Endotoxins Limits: Animals Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2007 Document type: Article Affiliation country: United States

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