Mutagenicity of some heterocyclic amines in Salmonella typhimurium with metabolic activation by human red blood cell cytosol.
Mutat Res
; 261(4): 261-5, 1991 Dec.
Article
in En
| MEDLINE
| ID: mdl-1722281
ABSTRACT
Purified human red blood cell cytosol was used to activate the heterocyclic amines 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ), 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) and 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) into mutagenic intermediate(s) in the Salmonella test. The liquid preincubation method in the presence of strain TA98 was utilized. In order to understand the mechanism involved in this metabolic activation, some modulators were incorporated in the medium. The results suggest that an oxygenated hemoprotein, probably oxyhemoglobin, is involved in the activation into genotoxic intermediate(s).
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quinolines
/
Carbolines
/
Cytosol
/
Mutagens
Limits:
Humans
Language:
En
Journal:
Mutat Res
Year:
1991
Document type:
Article
Affiliation country:
Belgium