Evidence for protein kinase C modulation of the ciliary muscle response to carbachol and desensitization.
Eur J Pharmacol
; 204(1): 49-53, 1991 Oct 29.
Article
in En
| MEDLINE
| ID: mdl-1725156
ABSTRACT
The role of protein kinase C (PKC) in the desensitization of muscarinic receptor-mediated responses in bovine ciliary muscle was examined. Exposure of the bovine ciliary muscle to phorbol esters, used to activate PKC, resulted in antagonism of muscarinic receptor-mediated contraction. On the other hand, staurosporine, a known PKC inhibitor, caused a significant potentiation of the contractile effect induced by carbachol. Staurosporine reduced the desensitization induced by repeated additions of carbachol and completely suppressed that induced by phorbol esters. The results also indicate that desensitization mediated by phorbol esters as well as that mediated by muscarinic receptor agonists is heterologous.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Protein Kinase C
/
Carbachol
/
Ciliary Body
/
Muscle, Smooth
Limits:
Animals
Language:
En
Journal:
Eur J Pharmacol
Year:
1991
Document type:
Article
Affiliation country:
Italy
Country of publication:
HOLANDA
/
HOLLAND
/
NETHERLANDS
/
NL
/
PAISES BAJOS
/
THE NETHERLANDS