Hemodynamic and humoral interactions between perindopril and indomethacin in essential hypertensive subjects.
J Cardiovasc Pharmacol
; 18 Suppl 7: S33-6, 1991.
Article
in En
| MEDLINE
| ID: mdl-1725198
ABSTRACT
To evaluate whether perindopril, a carboxyl-containing new angiotensin-converting enzyme (ACE) inhibitor, exerts its antihypertensive action through the stimulation of prostaglandin synthesis, 10 uncomplicated essential hypertensive patients randomly received indomethacin (50 mg b.i.d.) or the corresponding placebo for 1 week and the reverse treatment after 2 weeks. Perindopril alone tended to reduce serum and urinary thromboxane B2 (TxB2) and to raise urinary 6-ketoPGF1 alpha and PGE2 and inhibited serum ACE activity 24 h post dosing by about 85%. Indomethacin, which significantly inhibited serum TxB2 and urinary TxB2, 6-ketoPGF1 alpha, and PGE2 without interfering with the inhibitory effect of perindopril on ACE, significantly reduced the antihypertensive action of perindopril alone by about 30%, but decreased though not significantly that of perindopril plus placebo. Although the size of the study limits the interpretation, these findings suggest that the stimulation of prostaglandin synthesis plays only a minor role in the antihypertensive action of perindopril.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blood Pressure
/
Angiotensin-Converting Enzyme Inhibitors
/
Prostaglandins
/
Indomethacin
/
Hypertension
/
Indoles
Type of study:
Clinical_trials
Limits:
Adult
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Cardiovasc Pharmacol
Year:
1991
Document type:
Article
Affiliation country:
Italy