Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase.

Bhattacharyya, Sandip; Brown, Diane E; Brewer, Judson A; Vogt, Sherri K; Muglia, Louis J

Bhattacharyya, Sandip; Brown, Diane E; Brewer, Judson A; Vogt, Sherri K; Muglia, Louis J.

Affiliation

Bhattacharyya S; Departments of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA.

Blood ; 109(10): 4313-9, 2007 May 15.

Article in En | MEDLINE | ID: mdl-17255352

Subject(s)

Inflammation/immunology; Inflammation/metabolism; Macrophages/physiology; Receptors, Glucocorticoid/physiology; Toll-Like Receptor 4/physiology; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors; Animals; Cell Cycle Proteins/metabolism; Cytokines/metabolism; Dexamethasone/pharmacology; Dual Specificity Phosphatase 1; Enzyme Inhibitors/pharmacology; Immediate-Early Proteins/metabolism; Inflammation/chemically induced; Inflammation/mortality; Inflammation Mediators/metabolism; Lipopolysaccharides/pharmacology; Macrophages/metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Phosphoprotein Phosphatases/metabolism; Protein Phosphatase 1; Protein Tyrosine Phosphatases/metabolism; Receptors, Glucocorticoid/genetics; Receptors, Glucocorticoid/metabolism; Toll-Like Receptor 4/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Glucocorticoid / P38 Mitogen-Activated Protein Kinases / Toll-Like Receptor 4 / Inflammation / Macrophages Limits: Animals Language: En Journal: Blood Year: 2007 Document type: Article Affiliation country: United States Country of publication: United States

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