Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation.

Gao, Ben-Bo; Clermont, Allen; Rook, Susan; Fonda, Stephanie J; Srinivasan, Vivek J; Wojtkowski, Maciej; Fujimoto, James G; Avery, Robert L; Arrigg, Paul G; Bursell, Sven-Erik; Aiello, Lloyd Paul; Feener, Edward P

Gao, Ben-Bo; Clermont, Allen; Rook, Susan; Fonda, Stephanie J; Srinivasan, Vivek J; Wojtkowski, Maciej; Fujimoto, James G; Avery, Robert L; Arrigg, Paul G; Bursell, Sven-Erik; Aiello, Lloyd Paul; Feener, Edward P.

Affiliation

Gao BB; Research Division, Joslin Diabetes Center, One Joslin Place, Harvard Medical School, Boston, Massachusetts 02215, USA.

Nat Med ; 13(2): 181-8, 2007 Feb.

Article in En | MEDLINE | ID: mdl-17259996

Subject(s)

Capillary Permeability/drug effects; Carbonic Anhydrase Inhibitors/therapeutic use; Carbonic Anhydrases/metabolism; Diabetic Retinopathy/drug therapy; Eye Proteins/metabolism; Kallikrein-Kinin System/physiology; Vitreous Body/enzymology; Acetazolamide/pharmacology; Animals; Blotting, Western; Bradykinin Receptor Antagonists; Carbonic Anhydrase Inhibitors/pharmacology; Carbonic Anhydrases/toxicity; Complement C1/antagonists & inhibitors; Factor XIIa/metabolism; Humans; Mass Spectrometry; Papilledema/chemically induced; Proteomics; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric

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Collection: 01-internacional Database: MEDLINE Main subject: Vitreous Body / Capillary Permeability / Carbonic Anhydrase Inhibitors / Kallikrein-Kinin System / Carbonic Anhydrases / Diabetic Retinopathy / Eye Proteins Limits: Animals / Humans Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2007 Document type: Article Affiliation country: United States Country of publication: United States

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