Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel antiproliferative agents: exploration of core and headpiece structure-activity relationships.

Powell, Dennis; Gopalsamy, Ariamala; Wang, Yanong D; Zhang, Nan; Miranda, Miriam; McGinnis, John P; Rabindran, Sridhar K

Powell, Dennis; Gopalsamy, Ariamala; Wang, Yanong D; Zhang, Nan; Miranda, Miriam; McGinnis, John P; Rabindran, Sridhar K.

Affiliation

Powell D; Chemical and Screening Sciences, Wyeth Research, Pearl River, NY 10965, USA. powelld@wyeth.com

Bioorg Med Chem Lett ; 17(6): 1641-5, 2007 Mar 15.

Article in En | MEDLINE | ID: mdl-17275298

Subject(s)

Amides/chemical synthesis; Amides/pharmacology; Cell Proliferation/drug effects; Pyrimidines/chemical synthesis; Pyrimidines/pharmacology; Cell Cycle/drug effects; Cell Line, Tumor; Colonic Neoplasms/drug therapy; Colonic Neoplasms/pathology; Computer Simulation; Drug Evaluation, Preclinical; Humans; Indicators and Reagents; Models, Molecular; Molecular Conformation; Oncogene Protein p21(ras)/antagonists & inhibitors; Structure-Activity Relationship; Tumor Suppressor Protein p53/antagonists & inhibitors

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Cell Proliferation / Amides Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2007 Document type: Article Affiliation country: United States Country of publication: United kingdom

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