Exposure of male rats to cyclophosphamide alters the chromatin structure and basic proteome in spermatozoa.

Codrington, A M; Hales, B F; Robaire, B

Codrington, A M; Hales, B F; Robaire, B.

Affiliation

Codrington AM; Department of Pharmacology, McGill University, Montreal, Quebec, Canada.

Hum Reprod ; 22(5): 1431-42, 2007 May.

Article in En | MEDLINE | ID: mdl-17303633

Subject(s)

Antineoplastic Agents, Alkylating/pharmacology; Chromatin/drug effects; Chromatin/ultrastructure; Cyclophosphamide/pharmacology; Proteome/drug effects; Spermatozoa/drug effects; Animals; Antineoplastic Agents, Alkylating/administration & dosage; Chromomycin A3/metabolism; Cyclophosphamide/administration & dosage; Dithiothreitol/pharmacology; Fluorescent Antibody Technique; Male; Protamines/metabolism; Rats; Rats, Sprague-Dawley; Sperm Head/metabolism; Spermatozoa/metabolism; Sulfhydryl Compounds/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Spermatozoa / Chromatin / Antineoplastic Agents, Alkylating / Proteome / Cyclophosphamide Limits: Animals Language: En Journal: Hum Reprod Journal subject: MEDICINA REPRODUTIVA Year: 2007 Document type: Article Affiliation country: Canada Country of publication: United kingdom

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