DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Endoplasmic Reticulum/metabolism; Tumor Suppressor Proteins/genetics; Tumor Suppressor Proteins/metabolism; Ubiquitin-Protein Ligases/genetics; Ubiquitin-Protein Ligases/metabolism; Adenosine Triphosphatases/metabolism; Amino Acid Sequence; Cell Cycle Proteins/metabolism; Cell Line; DNA-Binding Proteins/antagonists & inhibitors; DNA-Binding Proteins/chemistry; Humans; Membrane Proteins/antagonists & inhibitors; Membrane Proteins/chemistry; Membrane Proteins/genetics; Membrane Proteins/metabolism; Molecular Sequence Data; Proteasome Endopeptidase Complex/metabolism; Protein Structure, Tertiary; RNA, Small Interfering/genetics; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Transfection; Tumor Suppressor Proteins/antagonists & inhibitors; Tumor Suppressor Proteins/chemistry; Ubiquitin/metabolism; Ubiquitin-Protein Ligases/antagonists & inhibitors; Ubiquitin-Protein Ligases/chemistry; Valosin Containing Protein