Combination of EGFR gene copy number and protein expression predicts outcome for advanced non-small-cell lung cancer patients treated with gefitinib.

Hirsch, F R; Varella-Garcia, M; Cappuzzo, F; McCoy, J; Bemis, L; Xavier, A C; Dziadziuszko, R; Gumerlock, P; Chansky, K; West, H; Gazdar, A F; Crino, L; Gandara, D R; Franklin, W A; Bunn, P A

Hirsch, F R; Varella-Garcia, M; Cappuzzo, F; McCoy, J; Bemis, L; Xavier, A C; Dziadziuszko, R; Gumerlock, P; Chansky, K; West, H; Gazdar, A F; Crino, L; Gandara, D R; Franklin, W A; Bunn, P A.

Affiliation

Hirsch FR; Division of Medical Oncology, Department of Medicine, University of Colorado Health Sciences Center and Cancer Center, Aurora, CO 80010, USA.

Ann Oncol ; 18(4): 752-60, 2007 Apr.

Article in En | MEDLINE | ID: mdl-17317677

Subject(s)

Carcinoma, Non-Small-Cell Lung/drug therapy; ErbB Receptors/genetics; Gene Dosage; Lung Neoplasms/drug therapy; Quinazolines/therapeutic use; Carcinoma, Non-Small-Cell Lung/genetics; Carcinoma, Non-Small-Cell Lung/mortality; ErbB Receptors/analysis; Female; Gefitinib; Genes, erbB-2; Genes, ras; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Lung Neoplasms/genetics; Lung Neoplasms/mortality; Male; Mutation; Treatment Outcome

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Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / Carcinoma, Non-Small-Cell Lung / Gene Dosage / ErbB Receptors / Lung Neoplasms Type of study: Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male Language: En Journal: Ann Oncol Journal subject: NEOPLASIAS Year: 2007 Document type: Article Affiliation country: United States Country of publication: United kingdom

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