Quantitative tumor perfusion assessment with multidetector CT: are measurements from two commercial software packages interchangeable?
Radiology
; 242(3): 777-82, 2007 Mar.
Article
in En
| MEDLINE
| ID: mdl-17325066
ABSTRACT
PURPOSE:
To prospectively determine the level of agreement between tumor blood volume and permeability measurements obtained with two commercially available perfusion computed tomographic (CT) software packages. MATERIALS ANDMETHODS:
This study was performed with institutional review board approval; informed consent was obtained from all participants. A total of 44 patients (24 men, 20 women; mean age, 68 years; range, 28-87 years) with proved colorectal cancer were examined prospectively with multi-detector row CT. A 65-second tumor perfusion study was performed after intravenous bolus injection of contrast material. Tumor blood volume and permeability were determined with twomethods:
adiabatic approximation of distributed parameter analysis and Patlak analysis. Agreement between the results was determined by using Bland-Altman statistics. Within-patient variation was determined by using analysis of variance.RESULTS:
The mean values for permeability and blood volume, respectively, were 13.9 mL x 100 mL(-1) x min(-1) +/- 3.7 (standard deviation) and 6.1 mL/100 mL +/- 1.5, as calculated with distributed parameter analysis, and 17.4 mL x 100 mL(-1) x min(-1) +/- 7.3 and 10.1 mL/100 mL +/- 4.2, as calculated with Patlak analysis. The mean difference and 95% limits of agreement, respectively, were -3.6 mL x 100 mL(-1) x min(-1) and -18.4 to 11.2 mL x 100 mL(-1) x min(-1) for permeability and -3.9 mL/100 mL and -10.9 to 3.0 mL/100 mL for blood volume. The coefficient of variation was 37.4% for permeability and 46.5% for blood volume.CONCLUSION:
There was disagreement between the methods used to estimate tumor vascularity, which indicated the measurement techniques were not directly interchangeable.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blood Flow Velocity
/
Blood Volume
/
Software
/
Colorectal Neoplasms
/
Neovascularization, Pathologic
Type of study:
Diagnostic_studies
/
Evaluation_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Radiology
Year:
2007
Document type:
Article
Affiliation country:
United kingdom