Differential constitutive activation of the epidermal growth factor receptor in non-small cell lung cancer cells bearing EGFR gene mutation and amplification.

Okabe, Takafumi; Okamoto, Isamu; Tamura, Kenji; Terashima, Masaaki; Yoshida, Takeshi; Satoh, Taroh; Takada, Minoru; Fukuoka, Masahiro; Nakagawa, Kazuhiko

Okabe, Takafumi; Okamoto, Isamu; Tamura, Kenji; Terashima, Masaaki; Yoshida, Takeshi; Satoh, Taroh; Takada, Minoru; Fukuoka, Masahiro; Nakagawa, Kazuhiko.

Affiliation

Okabe T; Department of Medical Oncology, Kinki University School of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511, Japan.

Cancer Res ; 67(5): 2046-53, 2007 Mar 01.

Article in En | MEDLINE | ID: mdl-17332333

Subject(s)

Carcinoma, Non-Small-Cell Lung/genetics; ErbB Receptors/genetics; Gene Amplification; Gene Expression Regulation, Neoplastic; Lung Neoplasms/genetics; Mutation; Base Sequence; Cell Proliferation/drug effects; DNA Mutational Analysis; ErbB Receptors/metabolism; Gefitinib; Humans; Molecular Sequence Data; Phosphorylation; Protein-Tyrosine Kinases/metabolism; Quinazolines/pharmacology; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation, Neoplastic / Gene Amplification / Carcinoma, Non-Small-Cell Lung / ErbB Receptors / Lung Neoplasms / Mutation Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cancer Res Year: 2007 Document type: Article Affiliation country: Japan Country of publication: United States

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