Hypoosmotic swelling and ammonia increase oxidative stress by NADPH oxidase in cultured astrocytes and vital brain slices.

Reinehr, Roland; Görg, Boris; Becker, Stephan; Qvartskhava, Natalia; Bidmon, Hans J; Selbach, Oliver; Haas, Helmut L; Schliess, Freimut; Häussinger, Dieter

Reinehr, Roland; Görg, Boris; Becker, Stephan; Qvartskhava, Natalia; Bidmon, Hans J; Selbach, Oliver; Haas, Helmut L; Schliess, Freimut; Häussinger, Dieter.

Affiliation

Reinehr R; Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Moorenstrasse 5, D-40225 Düsseldorf, Germany.

Glia ; 55(7): 758-71, 2007 May.

Article in En | MEDLINE | ID: mdl-17352382

Subject(s)

Brain Edema/metabolism; Hepatic Encephalopathy/metabolism; Hyperammonemia/metabolism; NADPH Oxidases/metabolism; Oxidative Stress; Ammonia/metabolism; Ammonia/toxicity; Animals; Animals, Newborn; Astrocytes/drug effects; Astrocytes/metabolism; Brain/drug effects; Brain/metabolism; Brain/physiopathology; Brain Edema/physiopathology; Cells, Cultured; Enzyme Inhibitors/pharmacology; Hepatic Encephalopathy/physiopathology; Hyperammonemia/physiopathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidases/genetics; Organ Culture Techniques; Osmotic Pressure; Rats; Rats, Wistar; Reactive Oxygen Species/metabolism; Water-Electrolyte Balance/drug effects; Water-Electrolyte Balance/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Brain Edema / Hepatic Encephalopathy / Oxidative Stress / NADPH Oxidases / Hyperammonemia Limits: Animals Language: En Journal: Glia Journal subject: NEUROLOGIA Year: 2007 Document type: Article Affiliation country: Germany Country of publication: United States

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